High Frequency of Shared Clonotypes in Human T Cell Receptor Repertoires
نویسندگان
چکیده
منابع مشابه
Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires
The diversity of T-cell receptors recognizing foreign pathogens is generated through a highly stochastic recombination process, making the independent production of the same sequence rare. Yet unrelated individuals do share receptors, which together constitute a "public" repertoire of abundant clonotypes. The TCR repertoire is initially formed prenatally, when the enzyme inserting random nucleo...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2020
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2020.107882